{"id":3293,"date":"2025-05-10T13:33:51","date_gmt":"2025-05-10T16:33:51","guid":{"rendered":"https:\/\/tdah.world\/en\/?p=3293"},"modified":"2025-05-05T14:43:31","modified_gmt":"2025-05-05T17:43:31","slug":"can-probiotic-help-dhd-hyperactivity-study-brain","status":"publish","type":"post","link":"https:\/\/tdah.world\/en\/can-probiotic-help-dhd-hyperactivity-study-brain\/","title":{"rendered":"Can Early-Life Probiotics Help with ADHD Hyperactivity? Rat Study Explores the Gut-Brain-Immune Connection"},"content":{"rendered":"<p><a href=\"https:\/\/tdah.world\/en\">ADHD (Attention-Deficit\/Hyperactivity Disorder)<\/a> is a complex condition, and science is constantly seeking to better understand its causes and explore new paths for intervention. One area drawing increasing attention is the connection between the gut and the brain\u2014the so-called gut-brain axis. Could the bacteria living in our intestines (the microbiota) actually influence ADHD symptoms?<\/p>\n<p>To explore this idea, researchers focused on early probiotic intervention in ADHD. They conducted a study using female SHR rats and <em>Bifidobacterium<\/em> BD-1. SHR rats are a well-established animal model for ADHD, known for showing hyperactive behavior from a young age. <em>Bifidobacterium bifidum<\/em> BD-1 is a type of \u201cgood\u201d bacteria commonly found in the intestines of healthy infants.<\/p>\n<p><strong>Read more:<\/strong> <\/p>\n\n    <div class=\"afiliado-card\">\n                    <div class=\"afiliado-imagem-container\">\n                 <a href=\"https:\/\/amzn.to\/4iFwBXc\" target=\"_blank\" rel=\"noopener sponsored\">\n                    <img decoding=\"async\" class=\"afiliado-imagem\" src=\"https:\/\/c.media-amazon.com\/images\/I\/71qVXP7Nz3L._SY466_.jpg\" alt=\"Anxiety: The Silent Epidemic of the 21st Century by Augusto Cury, PhD\" title=\"\">\n                 <\/a>\n            <\/div>\n        \n        <div class=\"afiliado-conteudo\">\n            <h2 class=\"afiliado-titulo\">Anxiety: The Silent Epidemic of the 21st Century by Augusto Cury, PhD<\/h2>\n            <p class=\"afiliado-descricao\">Confira este produto especial!<\/p>\n            <a class=\"afiliado-botao\" href=\"https:\/\/amzn.to\/4iFwBXc\" target=\"_blank\" rel=\"noopener sponsored\">\n                Buy here, now!!!            <\/a>\n        <\/div>\n    <\/div>\n    \n\n\n<h2>The Experiment: Probiotic from Birth<\/h2>\n<p>Here\u2019s what the researchers did:<\/p>\n<ol>\n<li><strong>Groups:<\/strong> They selected newborn female SHR rats (an established ADHD model) and WKY rats (used as a normal control group).<\/li>\n<li><strong>Intervention:<\/strong> One group of SHR rats received the probiotic <em>Bifidobacterium bifidum<\/em> BD-1 daily, starting at birth and continuing until 3 weeks of age (weaning period). Another group of SHR rats and all WKY rats received only saline (placebo).<\/li>\n<li><strong>Assessments:<\/strong> When the rats reached 7 weeks old (juvenile stage), the researchers conducted the following evaluations:<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<p><strong>Behavior:<\/strong> Measured hyperactivity levels using an open field test.<\/p>\n<\/li>\n<li>\n<p><strong>Gut Microbiota:<\/strong> Analyzed fecal bacteria at 3 and 7 weeks using 16S rRNA sequencing.<\/p>\n<\/li>\n<li>\n<p><strong>Brain:<\/strong> Measured key dopamine-related markers (Th and DAT, which play a role in ADHD) in the striatum, and inflammation markers in the prefrontal cortex.<\/p>\n<\/li>\n<li>\n<p><strong>Immune System:<\/strong> Counted regulatory T cells (Tregs), which help manage inflammation, in immune organs and in the bloodstream.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p class=\"\" data-start=\"4708\" data-end=\"4784\"><strong><em data-start=\"4708\" data-end=\"4784\">Also read: <a title=\"ADHD and the Art of Thinking Fast and Slow\" href=\"https:\/\/tdah.world\/en\/adhd-and-the-art-of-thinking-fast-and-slow\/\" target=\"_blank\" rel=\"noopener\"><span class=\"suggestion-title\" data-fk=\"[&quot;adhd&quot;]\"><a title=\"ADHD and Time Perception: How Brain Stimulation Can Help\" href=\"https:\/\/tdah.world\/en\/adhd-and-time-perception-how-brain-stimulation-can-help\/\" target=\"_blank\" rel=\"noopener\">ADHD and Time Perception: How Brain Stimulation Can Help<\/a><\/span><\/a><\/em><\/strong><\/p>\n\n    <div class=\"afiliado-card\">\n                    <div class=\"afiliado-imagem-container\">\n                 <a href=\"https:\/\/amzn.to\/4489QYp\" target=\"_blank\" rel=\"noopener sponsored\">\n                    <img decoding=\"async\" class=\"afiliado-imagem\" src=\"https:\/\/c.media-amazon.com\/images\/I\/71Vj09Usi9L._SX445_.jpg\" alt=\"Bobbie Goods\" title=\"\">\n                 <\/a>\n            <\/div>\n        \n        <div class=\"afiliado-conteudo\">\n            <h2 class=\"afiliado-titulo\">Bobbie Goods<\/h2>\n            <p class=\"afiliado-descricao\">Bobbie Goods Postcard Coloring Book combines creativity and connection in a delightful collection of pullout postcards.<\/p>\n            <a class=\"afiliado-botao\" href=\"https:\/\/amzn.to\/4489QYp\" target=\"_blank\" rel=\"noopener sponsored\">\n                Buy here, now!!!            <\/a>\n        <\/div>\n    <\/div>\n    \n\n\n<h3>Remarkable Findings: The Effects of <em>Bifidobacterium bifidum<\/em> BD-1 on ADHD (Animal Model)<\/h3>\n<p>The results revealed several notable effects of <em>Bifidobacterium bifidum<\/em> BD-1 on ADHD-like symptoms in SHR rats:<\/p>\n<p><strong>\u00a0Reduced Hyperactivity: <\/strong>SHR rats that received <em>B. bifidum<\/em> BD-1 early in life were significantly less hyperactive at 7 weeks old compared to untreated SHR rats.<\/p>\n<p><strong>Gut Microbiota Modulation: <\/strong>Early probiotic intervention altered the gut microbiome composition in meaningful ways. In BD-1 treated rats, researchers observed:<\/p>\n<ul>\n<li>\n<p><strong>Increased alpha diversity<\/strong> (more types of gut bacteria, generally considered beneficial)<\/p>\n<\/li>\n<li>\n<p><strong>Lower F\/B ratio<\/strong> (the Firmicutes\/Bacteroidota ratio, often linked to metabolic and inflammatory imbalances)<\/p>\n<\/li>\n<li>\n<p><strong>Higher levels of beneficial bacteria<\/strong>, such as <em>Muribaculaceae<\/em><\/p>\n<\/li>\n<li>\n<p><strong>Lower levels of potentially pro-inflammatory bacteria<\/strong>, such as <em>Clostridia_UCG-014<\/em><\/p>\n<\/li>\n<\/ul>\n<p>These changes highlight the potential importance of gut microbiota modulation in childhood ADHD\u2014at least within this animal model.<\/p>\n<p><strong>Reduced Brain Inflammation: <\/strong>Rats treated with BD-1 showed fewer markers of neuroinflammation\u2014specifically, less activated microglia in the prefrontal cortex. This suggests a possible link between the reduction of <em>Clostridia_UCG-014<\/em> and decreased brain inflammation in ADHD.<\/p>\n<p><strong>Improved Peripheral Immunity: <\/strong>There was a notable increase in regulatory T cells (Tregs) in the spleen of BD-1 treated rats. Tregs help &#8220;calm&#8221; the immune system, and their naturally low numbers in SHR rats point to an immune imbalance that the probiotic appears to have helped restore. This strengthens the theory of a gut-immune-behavior connection in ADHD.<\/p>\n<p><strong>Positive Impact on the Dopaminergic System: <\/strong>SHR rats typically showed lower levels of key dopamine-related markers (Th and DAT) in the striatum. Treatment with BD-1 increased Th levels\u2014a crucial enzyme for dopamine synthesis\u2014indicating a possible improvement in dopamine function, which plays a central role in ADHD symptoms.<\/p>\n<p class=\"\" data-start=\"4708\" data-end=\"4784\"><strong><em data-start=\"4708\" data-end=\"4784\">Also read: <span class=\"suggestion-title\" data-fk=\"[&quot;adhd&quot;]\"><a title=\"Decisions in ADHD Treatment: How to Involve the Whole Family\" href=\"https:\/\/tdah.world\/en\/decisions-in-adhd-treatment-how-to-involve-the-whole-family\/\" target=\"_blank\" rel=\"noopener\">Decisions in ADHD Treatment: How to Involve the Whole Family<\/a><\/span><br \/><\/em><\/strong><\/p>\n\n    <div class=\"afiliado-card\">\n                    <div class=\"afiliado-imagem-container\">\n                 <a href=\"https:\/\/amzn.to\/4489QYp\" target=\"_blank\" rel=\"noopener sponsored\">\n                    <img decoding=\"async\" class=\"afiliado-imagem\" src=\"https:\/\/c.media-amazon.com\/images\/I\/71Vj09Usi9L._SX445_.jpg\" alt=\"Bobbie Goods\" title=\"\">\n                 <\/a>\n            <\/div>\n        \n        <div class=\"afiliado-conteudo\">\n            <h2 class=\"afiliado-titulo\">Bobbie Goods<\/h2>\n            <p class=\"afiliado-descricao\">Bobbie Goods Postcard Coloring Book combines creativity and connection in a delightful collection of pullout postcards.<\/p>\n            <a class=\"afiliado-botao\" href=\"https:\/\/amzn.to\/4489QYp\" target=\"_blank\" rel=\"noopener sponsored\">\n                Buy here, now!!!            <\/a>\n        <\/div>\n    <\/div>\n    \n\n\n<h3 class=\"\" data-start=\"3267\" data-end=\"3309\">The Gut-Brain-Immune Axis in Action<\/h3>\n<p class=\"\" data-start=\"3311\" data-end=\"3413\">This study provides <strong data-start=\"3331\" data-end=\"3356\">animal-based evidence<\/strong> that early modulation of the gut microbiota in ADHD may:<\/p>\n<ol data-start=\"3414\" data-end=\"3577\">\n<li class=\"\" data-start=\"3414\" data-end=\"3433\">\n<p class=\"\" data-start=\"3416\" data-end=\"3433\">Balance gut flora<\/p>\n<\/li>\n<li class=\"\" data-start=\"3434\" data-end=\"3461\">\n<p class=\"\" data-start=\"3436\" data-end=\"3461\">Reduce brain inflammation<\/p>\n<\/li>\n<li class=\"\" data-start=\"3462\" data-end=\"3489\">\n<p class=\"\" data-start=\"3464\" data-end=\"3489\">Improve immune regulation<\/p>\n<\/li>\n<li class=\"\" data-start=\"3490\" data-end=\"3531\">\n<p class=\"\" data-start=\"3492\" data-end=\"3531\">Enhance dopamine-related brain function<\/p>\n<\/li>\n<li class=\"\" data-start=\"3532\" data-end=\"3577\">\n<p class=\"\" data-start=\"3534\" data-end=\"3577\">Ultimately, <strong data-start=\"3546\" data-end=\"3577\">reduce hyperactive behavior<\/strong><\/p>\n<\/li>\n<\/ol>\n<h3 class=\"\" data-start=\"3584\" data-end=\"3627\">Future Possibilities (With Caution!)<\/h3>\n<p class=\"\" data-start=\"3629\" data-end=\"3689\">These results are exciting, but there are important caveats:<\/p>\n<ul data-start=\"3691\" data-end=\"3982\">\n<li class=\"\" data-start=\"3691\" data-end=\"3759\">\n<p class=\"\" data-start=\"3693\" data-end=\"3759\"><strong data-start=\"3693\" data-end=\"3710\">Animal Model:<\/strong> Rats are not humans. Human trials are essential.<\/p>\n<\/li>\n<li class=\"\" data-start=\"3760\" data-end=\"3851\">\n<p class=\"\" data-start=\"3762\" data-end=\"3851\"><strong data-start=\"3762\" data-end=\"3782\">Strain-Specific:<\/strong> Only <em data-start=\"3788\" data-end=\"3800\">B. bifidum<\/em> BD-1 was tested. Not all probiotics work the same.<\/p>\n<\/li>\n<li class=\"\" data-start=\"3852\" data-end=\"3982\">\n<p class=\"\" data-start=\"3854\" data-end=\"3982\"><strong data-start=\"3854\" data-end=\"3874\">Early-Life Only:<\/strong> The probiotic was administered from birth. We don\u2019t know if later interventions would have similar effects.<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"3989\" data-end=\"4038\">Final Thoughts: Healthy Gut, Calmer Brain?<\/h3>\n<p>The connection between the gut, the immune system, and the brain is one of the most exciting frontiers in neuroscience and mental health research. This study using SHR rats and the probiotic <em>B. bifidum<\/em> BD-1 adds an important piece to the puzzle, showing that early modulation of the gut microbiota in childhood ADHD (in an animal model) may influence the link between immunity and hyperactive behavior.<\/p>\n<p>While it&#8217;s still too early to recommend probiotics as a standard treatment for ADHD, this research strengthens the idea that a healthy gut supports a healthy brain\u2014starting from the very first days of life.<\/p>\n<p class=\"\" data-start=\"4708\" data-end=\"4784\"><strong><em data-start=\"4708\" data-end=\"4784\">Also read: <span class=\"suggestion-title\" data-fk=\"[&quot;adhd&quot;]\"><a title=\"The Complete Guide to ADHD Treatment\" href=\"https:\/\/tdah.world\/en\/the-complete-guide-to-adhd-treatment\/\" target=\"_blank\" rel=\"noopener\">The Complete Guide to ADHD Treatment<\/a><\/span><\/em><\/strong><\/p>\n\n\n<div class=\"wp-block-essential-blocks-advanced-tabs alignwide  root-eb-advanced-tabs-y78rc\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-tabs-y78rc \"><div class=\"eb-advanced-tabs-y78rc eb-advanced-tabs-wrapper horizontal\" data-min-height=\"true\"><div class=\"eb-tabs-nav\"><ul class=\"tabTitles\" data-tabs-ul-id=\"eb-advanced-tabs-y78rc\"><li data-title-tab-id=\"1\" data-title-custom-id=\"\" class=\"active\"><i icon=\"fas fa-home\" class=\"fas fa-home tabIcon\"><\/i><h6 class=\"tab-title-text\">References<\/h6><\/li><li data-title-tab-id=\"2\" class=\"inactive\"><i icon=\"fas fa-home\" class=\"fas fa-home tabIcon\"><\/i><h6 class=\"tab-title-text\">Learn More<\/h6><\/li><\/ul><\/div><div class=\"eb-tabs-contents\">\n<div class=\"eb-tab-wrapper\" data-tab-id=\"1\" data-tab-parent-id=\"eb-advanced-tabs-y78rc\"><div class=\"eb-tab-inner\">\n<p><strong>Author:<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Castells+X&amp;cauthor_id=30091808\" target=\"_blank\" rel=\"noopener\">Xavier Castells<\/a><\/p>\n\n\n\n<p><strong>Sorce:<\/strong>&nbsp;<em><em><em><em><em><em><em><em><em><em><em><em><em><em>Affiliations<\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/em><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"eb-tab-wrapper\" data-tab-id=\"2\" data-tab-parent-id=\"eb-advanced-tabs-y78rc\"><div class=\"eb-tab-inner\">\n<p><strong>Original Research:&nbsp;<\/strong>Oepn acesses<br>\u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30091808\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30091808\/\" target=\"_blank\" rel=\"noopener\">Amphetamines for attention deficit hyperactivity disorder (ADHD) in adults<\/a>&#8221; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Castells+X&amp;cauthor_id=30091808\" target=\"_blank\" rel=\"noopener\">Xavier Castells<\/a> et. al Affiliations<\/p>\n<\/div><\/div>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-0ca21ea1 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\">\n<h2 class=\"wp-block-heading\"><strong><strong>FAQ \u2014 Amphetamines for Adult ADHD: Effectiveness, Safety, and Key Insights<\/strong><br><\/strong><\/h2>\n\n\n<div class=\"wp-block-uagb-faq uagb-faq__outer-wrap uagb-block-d21e7e4c uagb-faq-icon-row uagb-faq-layout-accordion uagb-faq-expand-first-true uagb-faq-inactive-other-true uagb-faq__wrap uagb-buttons-layout-wrap uagb-faq-equal-height     \" data-faqtoggle=\"true\" role=\"tablist\"><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-616e26cc \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong>1. Do amphetamines like Vyvanse\u00ae and Adderall\u00ae really work for adult ADHD?<\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>Yes, according to the Cochrane Review, amphetamines such as lisdexamfetamine (Vyvanse\u00ae) and mixed amphetamine salts (Adderall\u00ae) have been shown to reduce ADHD symptoms in adults in the short term. However, the quality of this evidence is rated as low to very low.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-21e11357 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>2. Is there a difference between lisdexamfetamine, dextroamphetamine, and Adderall\u00ae?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>Yes. Lisdexamfetamine and Adderall\u00ae showed clearer effectiveness in reducing symptoms compared to placebo. Dextroamphetamine alone had less consistent results, especially in clinician assessments.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-02cdd50f \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>3. Are amphetamines safe for long-term use in adults with ADHD?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>There\u2019s limited evidence regarding long-term safety. Most studies lasted only a few weeks. While short-term use showed effectiveness, higher dropout rates due to side effects raise concerns about prolonged treatment.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-221f7954 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>4. What are the common side effects of amphetamines?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>Typical side effects include insomnia, loss of appetite, dry mouth, anxiety, irritability, headaches, nausea, increased blood pressure, and faster heart rate.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-595af507 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong>5. Do amphetamines increase cardiovascular risk?<\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>In short-term studies, no significant difference was found between amphetamines and placebo regarding cardiovascular issues. However, due to the short duration and low-quality evidence, long-term cardiovascular risks remain unclear.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-f50debe6 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>6. Do higher doses of amphetamines work better?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>No. The review found no evidence that higher doses lead to greater effectiveness in treating ADHD symptoms.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-3ae362b6 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>7. Is there a better type of amphetamine release\u2014immediate or extended?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>The review did not find clear differences in efficacy or safety between immediate-release and extended-release formulations.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-66853d62 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong><strong>8. Can adults with anxiety, depression, or substance abuse history use amphetamines safely?<\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>The available studies included few patients with these comorbidities. While mild cases didn\u2019t seem to impact effectiveness, more research is needed to understand safety and efficacy in complex cases.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-ffbd7578 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong>9. Are amphetamines better than other ADHD medications like modafinil or guanfacine?<\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>There weren\u2019t enough studies comparing amphetamines to other medications. Therefore, no strong conclusions can be drawn about which treatment is superior.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-cac75939 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong><strong><strong>10. Should amphetamines be the first choice for treating adult ADHD?<\/strong><\/strong><\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>It depends on individual circumstances. Amphetamines can be effective but come with potential risks. Treatment decisions should always be personalized and made in consultation with a healthcare professional.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-ac44f619 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong>11. Do amphetamines help patients stay engaged in treatment?<\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>No. The review found that amphetamines did not improve treatment retention compared to placebo.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-8704f6b5 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong><strong>12. What should I consider before starting amphetamines for ADHD?<\/strong><\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>Discuss all options with your doctor, including non-stimulant medications and behavioral therapies. Monitor side effects closely and understand that medication works best as part of a comprehensive treatment plan.<\/p><\/div><\/div><div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-7395ca50 \" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\">\t\t\t<span class=\"uagb-icon uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M432 256c0 17.69-14.33 32.01-32 32.01H256v144c0 17.69-14.33 31.99-32 31.99s-32-14.3-32-31.99v-144H48c-17.67 0-32-14.32-32-32.01s14.33-31.99 32-31.99H192v-144c0-17.69 14.33-32.01 32-32.01s32 14.32 32 32.01v144h144C417.7 224 432 238.3 432 256z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"uagb-icon-active uagb-faq-icon-wrap\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox= \"0 0 448 512\"><path d=\"M400 288h-352c-17.69 0-32-14.32-32-32.01s14.31-31.99 32-31.99h352c17.69 0 32 14.3 32 31.99S417.7 288 400 288z\"><\/path><\/svg>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t<span class=\"uagb-question\"><strong>13.  Where can I find more information about ADHD?<\/strong><\/span><\/div><div class=\"uagb-faq-content\"><p>Talk to your trusted healthcare professional.<br>You can also read this other article, created by us at. <a href=\"https:\/\/tdah.world\/en\/\" data-type=\"link\" data-id=\"https:\/\/tdah.world\/en\/\">TDAH.world<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Could early probiotic intervention help reduce hyperactivity in ADHD? A study using Bifidobacterium bifidum BD-1 in rats reveals promising effects by linking the gut microbiome, immune system, and brain function.<\/p>\n","protected":false},"author":1,"featured_media":3286,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_uag_custom_page_level_css":"","footnotes":""},"categories":[472,431,428,13],"tags":[2028,2037,2036,1855,2031,2034,2033,2032,1699,2046,2025,2026,2041,2038,2052,2050,2035,2043,2042,2049,2030,2044,2045,2039,3,2047,2056,2053,2029,2055,2051,2048,2054,74,2057,2027,2040],"class_list":["post-3293","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diagnosis","category-efeitos-colaterais","category-medications","category-tratamentos-tdah","tag-adderall-adhd","tag-adhd-comorbidities","tag-adhd-drugs","tag-adhd-management","tag-adhd-medication","tag-adhd-safety","tag-adhd-side-effects","tag-adhd-stimulants","tag-adhd-treatment","tag-adhd-treatment-options-beyond-stimulants","tag-adult-adhd","tag-amphetamines-adhd","tag-are-amphetamines-safe-for-long-term-adhd-treatment","tag-best-medication-for-adult-adhd-treatment","tag-best-type-of-amphetamine-release-for-adhd-immediate-vs-extended","tag-cardiovascular-risks-of-amphetamines-in-adult-adhd","tag-cochrane-adhd","tag-cochrane-review-on-adhd-medications","tag-common-side-effects-of-adhd-stimulants","tag-comparing-amphetamines-to-modafinil-for-adhd","tag-dextroamphetamine","tag-differences-between-lisdexamfetamine-and-dextroamphetamine","tag-do-higher-doses-of-amphetamines-improve-adhd-symptoms","tag-effectiveness-of-amphetamines-for-adhd-in-adults","tag-hot-news","tag-how-amphetamines-affect-anxiety-and-depression-in-adhd-patients","tag-how-effective-is-vyvanse-for-adult-adhd","tag-impact-of-amphetamines-on-executive-function-in-adults-with-adhd","tag-lisdexamfetamine","tag-long-term-risks-of-adhd-medications","tag-managing-adhd-with-comorbid-substance-abuse","tag-retention-rates-in-adhd-stimulant-treatments","tag-should-amphetamines-be-first-line-treatment-for-adult-adhd","tag-staff-pick","tag-understanding-cochrane-findings-on-adhd-stimulants","tag-vyvanse-adhd","tag-vyvanse-vs-adderall-for-adhd-symptoms"],"acf":[],"a3_pvc":{"activated":false,"total_views":0,"today_views":0},"parsely":{"version":"1.1.0","canonical_url":"https:\/\/https:\/\/tdah.world\/en\/\/en\/can-probiotic-help-dhd-hyperactivity-study-brain\/","smart_links":{"inbound":0,"outbound":0},"traffic_boost_suggestions_count":0,"meta":{"@context":"https:\/\/schema.org","@type":"NewsArticle","headline":"Can Early-Life Probiotics Help with ADHD Hyperactivity? 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